CoenzymeQ10 Necessary For Life
Numerous Disease States Respond to CoenzymeQ10/Ubiquinone Supplementation
Coenzyme Q10 (CoQ10) is essential for the optimal functioning of all cell types. It is necessary for life and is required for energy production in all cells, including the heart, which contains enormous amounts of CoQ10. Most cells are able to synthesize this nutrient.
From the Pauling Institute at Oregon State University is the following quotation. "Coenzyme Q10 is soluble in lipids (fats) and is found in virtually all cell membranes, as well as lipoproteins" where it functions as an antioxidant.
The ability of the benzoquinone head group of coenzymeQ10 to accept and donate electrons is a critical feature in its biochemical functions. Coenzyme Q10 can exist in three oxidation states: (1) the fully reduced ubiquinol form (CoQ10H2), 2) the radical semiquinone intermediate (CoQ10H•), and 3) the fully oxidized ubiquinone form (CoQ10)."
The effect on a number of different diseases has been studied according to Peter Langsjoen, MD. Several diseases have responded favorably to CoQ10 administration, probably due to CoQ10s function as a free radical scavenger. It is a powerful anti-oxidant in addition to being necessary for cellular energy production.
Dr. Langsjoen has carried out research on heart disease using the fully oxidized and fully reduced form of Coenzyme Q10.
The Importance of CoenzymeQ10 (CoQ10)
CoenzymeQ10 is listed in the Physicians Desk Reference, 46th edition, 1992, as an "essential nutrient" necessary for every cell, tissue and organ in the body.
• It is necessary for the production of the main source of energy, ATP, in the mitochondria of all cells. Most of the hundreds of reactions in mammalian cells, require energy. ATP provides that energy.
• A form of CoQ10 maintains the integrity of cell membranes. This is important in nerve cells and muscles.
• Adequate levels of CoQ10 give protection against free radical mitochondrial damage, which was proposed in 1972 as the principal means of aging.
• CoQ10 gave complete protection from stroke in 3 animal models when started pre-stroke or 12 hours post stroke. These animal models all produced normal amounts of ascorbic acid in the liver from glucose
• An article in the November 2006 Reader’s Digests suggests that CoQ10 may be helpful in overcoming periodontal disease by promoting cell growth and healing of gum tissue.
Insufficient CoenzymeQ10 May Lead to Congestive Heart Failure
A number of physicians and scientists believe the epidemic proportions of heart failure today is due to the extensive use of statin drugs. These drugs lower cholesterol by inhibiting its synthesis, and also inhibit the synthesis of CoenzymeQ10.
Land Mark Study Proclaimed
An article in the November 10, 2008 Longview News-Journal had the headline "Study: Drug May Halve Heart Risks".
Study participants did not have high cholesterol or histories of heart disease
It has been known for a long time that statins can benefit a limited group of people by their action on inflammation but not by their ability to lower cholesterol.
The shortened study may also avoid revealing what many previous studies have shown that lowering cholesterol by artificial means can be dangerous.
What we need to know is how many patients actually had heart attacks compared to those who could be expected to have heart attacks in those patients who had demonstrable C Reactive Protein which is a marker for inflammation in the body.
Many in previous studies were shown not to benefit from statins. Apparently these could now be included in the group recommended for statins. Is this the benefit of the shortened study?
Could someone tell me why a study is lauded that delivers thousands, maybe millions, to the group that statins might benefit, but the URLs and many journal articles are ignored that promote the use and efficacy of CoQ10 and ascorbic acid.
These two essential nutrients cannot be patented, and therefore are unprofitable, but are effective, nontoxic, and inexpensive, and available over the counter.
Warnings About Statins and Effects on CoenzymeQ10
Karl Folkers was the brilliant chemist, who worked at Merck, and discovered the structure of Coenzyme Q10 and devised a synthetic scheme for the naturally occurring substance.
Merck apparently was uninterested in Folkers work, possibly because it could not be patented. Japan now provides most of the worldwide source of CoQ10.
Because of Folkers work CoQ10 is available as an over the counter supplement.
Statin Drugs May Be Dangerous
Karl Folkers warned that prescribed statin drugs, which inhibit cholesterol and CoQ10 synthesis, should include supplemental CoQ10 to prevent unintended damage to the patient. Apparently such a drug combination was prepared, but then not marketed because it might reflect negatively on statin drugs, like Mevacor, or Lipitor.
Too little CoQ10 leads to muscle wasting, heart failure (the heart is a muscle), and inflammation of tendons and ligaments, often leading to rupture.
CoQ10 reduces the cardiac toxicity of the cancer drug Adriamycin. The cardiac toxicity may relate to free radical generation and CoQ10 may be helpful in its capacity as a free radical scavenger.
The antioxidant or free radical scavenging effect of CoQ10 may significantly inhibit the oxidation of cholesterol in LDL particles. This ability may slow the development of atherosclerosis, and ultimately active heart disease.
“We have only scratched the surface of the biomedical and clinical applications of CoQ10 and the associated fields of bioenergetics and free radical chemistry.” claims Dr. Langsjoen in his paper INTRODUCTION TO COENZYME Q10.
An excellent review of CoenzymeQ10, and possible uses in the body and ongoing research to clarify its mode of action in disease processes is found at the University of Maryland Medical Center website. http://www.umm.edu/altmed/articles/coenzyme-q10-000295.htm
An excellent review is also found at the URL of the Pauling Institute at Oregon State.http://lpi.oregonstate.edu/infocenter/othernuts/coq10/ Copy and paste in your browser.
A cardiologist told me that if I wanted to save money I should forget about taking CoQ10. A recent journal article at the time reported the action of statin drugs was in the liver. Apparently he was unaware that statins not only inhibit cholesterol but also inhibit CoQ10. He apparently didn't know that CoQ10 is an essential nutrient necessary for life.
If the liver is the main place for cholesterol synthesis then it is the main place for CoQ10 synthesis also.
With so many required body functions why do mainstream physicians discourage the use of CoQ10. One source suggested this is the same as telling his captive patients we want you to suffer needlessly and even die sooner than necessary, and maybe just so the drug companies and I can make a comfortable living.
Some of the above came from an article entitled The Dangers of Statin Drugs: WhatYou Haven’t Been Told About Cholesterol Lowering Medication, Part 1 By Sally Fallon and Mary G. Enig, PhD. The article was originally printed at the Weston A. Price Foundation website. A current version of the article is found at the URL. http://www.westonaprice.org/moderndiseases/statin.html
Mayo Clinic View of CoenzymeQ10
The following 2 paragraphs are from the Mayo Clinic. "Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells. CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS. Some prescription drugs may also lower CoQ10 levels.
Levels of CoQ10 in the body can be increased by taking CoQ10 supplements, although it is not clear that replacing low CoQ10 is beneficial." Mayo Clinic URL is found at the text links below.
This Mayo Clinic statement sounds like a defense of the pharmaceutical drug industry. The Physicians Drug Reference (PDR) states that CoQ10 is an essential nutrient. Too low CoQ10 blood levels can result in death.
Pediatricians at the University of California at San Diego described a child that could not synthesize cholesterol. His cholesterol blood level was reported to be 70-79 mg/dl, which is very low.
The child was mentally retarded, had a very small head for his age, was profoundly anemic, could not maintain proper blood acidity, had frequent fevers, and cataracts. He died at age 24 months.
And to say that it is not clear that replacing low CoenzymeQ10 in times of deep stress could be beneficial is a curious statement at best.
It is in sharp contrast to a statement by a Washington University School of Medicine faculty member.
"----ubiquinone (CoQ10) body pool and turnover rate that mandate human supplementation".
After reviewing a number of studies about CoQ10 supplementation the Pauling institute makes this conclusion. "Presently, there is no scientific evidence that coenzyme Q10 supplementation prolongs life or prevents age-related functional declines in humans." This is in contrast to the statement below from a University of Washington School of Medicine faculty member.
A quotation from the The Science of Essential Nutrients draws the following conclusion at the URL http://faculty.washington.edu/ely/SciEssNutr.html Copy and paste in your web browser.
"Q10 supplementation is beneficial in the prevention, treatment or cure of heart disease, stroke, cancer, viral diseases including AIDS, etc. Q10 slowed aging markedly, restored youthful thymic response to viruses and tumors, and extended lifespan 50% when given to very old mice (Bliznakov, 1973). Safety and efficacy of Q10 has been demonstrated in numerous very large clinical trials (Langsjoen 1995; Langsjoen and Langsjoen 1999; Ely and Krone 2000)."
Tocotrienols: The Newest Part of the Vitamin E FamilyA Natural Way to Lower Cholesterol
Tocotrienols, particularly the gamma isomer, can reduce cholesterol synthesis, but they do not inhibit CoQ10 synthesis or the other important compounds dolichol, geranylgeraniol, and farnesol, as statins do.
"Therefore, tocotrienol dials down cholesterol synthesis without consequences, and statins shut down cholesterol synthesis with major consequences."
Statins inhibit all of these compounds as well as cholesterol and CoQ10. Along with the inhibition of these important compounds by statins are the unwanted side effects of myopathy, anemia, and chronic fatigue. Taking prescription drug statins, particularly in a time of stress, might be pretty close to a death sentence, since CoQ10 is an essential nutrient, necessary for life. Text links below open in a new window.
Wikipedia description of the vitamin E family.
Comparison of statins and tocotrienols on CoenzymeQ10 synthesis
Mayo Clinic statement about CoenzymeQ10 is found here.
The Home Page and definition of nutritional diseases.